Backed by evidence, not hype
Explore clinical trials investigating the benefits of the mushrooms in our drops
A placebo-controlled study in healthy young adults reported faster cognitive performance 60 minutes after a single dose, with a trend toward lower subjective stress by day 28.
Docherty et al., 2024 (PubMed)
In a randomized clinical trial, Lion's Mane improved cognitive test performance in older adults, and the gains faded after supplementation stopped, suggesting the benefit depends on consistent use.
Mori et al., 2009 (PubMed)
Young adult athletes taking a Cordyceps mushroom blend showed longer time-to-exhaustion after one week, with additional gains in VO2 max and ventilatory threshold after 3 weeks.
Hirsch et al., 2017 (PubMed)
In healthy older adults, a Cordyceps extract was associated with a significant gain in metabolic threshold (ventilatory threshold) versus placebo on a graded exercise test, suggesting better stamina and fatigue resistance during exertion.
Chen et al., 2010 (PubMed)
Patients with chronic physical and mental exhaustion (neurasthenia) taking an oral Reishi extract for eight weeks reported larger reductions in fatigue and greater clinician-rated improvement than placebo.
Tang et al., 2005 (PubMed)
In a cohort of breast cancer patients, Reishi powder improved physical well-being and fatigue scores, and participants also reported less anxiety, less depression, and better quality of life than controls.
Zhao et al., 2012 (PubMed)
Chaga extract significantly improved learning and memory while reducing oxidative and nitrosative stress markers and helping restore acetylcholine balance. Chaga showed promising support for helping the brain stay resilient under stress.
Giridharan et al., 2011 (PubMed)
This foundational study found Chaga extracts possess strong antioxidant activity against multiple free-radical systems, suggesting potential for protecting against oxidative stress and neuroinflammation.
Cui et al., 2005 (PubMed)
A 2026 clinical trial found that mushroom blends featuring Reishi and Maitake reduced psychological stress and fatigue, leading to more balanced energy and better sleep quality.
Hisamuddin et al., 2026 (PubMed)
Maitake has shown antidepressant-like effects in standard behavioral stress tests, and the authors linked the effect to AMPA receptor signaling. This suggests Maitake may help support emotional balance and resilience to everyday stress.
Bao et al., 2017 (PubMed)
In healthy adults exposed to different stress conditions, a cultured shiitake extract increased parasympathetic activity at rest, and in people with chronic mental stress it improved initiation and maintenance of sleep versus placebo.
Takanari et al., 2018 (PubMed)
In a randomized, placebo-controlled clinical trial, a shiitake-derived supplement improved overall well-being, with the benefit appearing strongest in people who started with lower baseline well-being.
Aldwinckle et al., 2020 (PubMed)
Turkey Tail mushroom supplementation was associated with improved psycho-emotional status and reduced chronic stress burden, suggesting support for a calmer sense of well-being in people under physiologic stress.
Di Paola et al., 2024 (PubMed)
A systematic review of 28 lung-cancer studies found that randomized trials of Turkey Tail supplementation showed benefits in performance status, body weight, and tumor-related symptoms such as fatigue and anorexia.
Fritz et al., 2015 (PubMed)
Educational information only—not medical advice. Research summaries do not guarantee individual results. This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.